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MRNA · Forward model · RSV vaccine (mRESVIA) · Bull case

What has to happen in RSV vaccine (mRESVIA)

Model as of

This page changes RSV vaccine (mRESVIA) inside the complete MRNA model. Every other vertical, corporate programme and valuation assumption stays in the selected portfolio case.

MRNA forward model
Horizon
Consolidated fair value $42.71 all other verticals held in this portfolio case
Final-quarter revenue $6M 2% of company revenue
Explicit segment contribution $48M EBITDA less segment capex, before corporate items

The three August 2026 events reach the revenue line: mFLUSIVA approved on 5 August for adults 50 and older in time for the 2026-27 season, the European Commission joint procurement for up to 24 million mRESVIA doses, and the first positive Phase 3 for an individualised neoantigen therapy on 19 August. None of the three is in guidance. This case expresses them as a compounding tilt across the whole franchise; it does NOT reach cash breakeven in 2028, and it books no intismeran revenue, because Merck leads that commercialisation.

RSV vaccine (mRESVIA)

Basis quarter$3M
Final quarter$6M
Implied CAGR+16%
Final revenue mix2%

mRESVIA is approved in 40 countries and has never earned more than $15M in a quarter; eight post-launch quarters total $43M. The European Commission joint procurement signed in Q2 2026 for up to 24 million doses is the first contract large enough to change that, and it carries no disclosed price, value or delivery schedule.

Last four quarters
2025 Q3 $2M Reported
2025 Q4 $4M Estimated
2026 Q1 $7M Reported
2026 Q2 $3M Reported
mRESVIA (mRNA-1345)
Sequential growth +1.5%/qtr decaying toward +1.0% Held on the disclosed run rate. The EC procurement has no published price or schedule, so it cannot be sized without inventing one.
RSV vaccine (mRESVIA)

Latest: $6M (2031Q2E)

Period Value
2023Q1 $0.00
2023Q2 $0.00
2023Q3 $0.00
2023Q4 $0.00
2024Q1 $0.00
2024Q2 $0.00
2024Q3 $10M
2024Q4 $15M
2025Q1 $2M
2025Q2 $0.00
2025Q3 $2M
2025Q4 $4M
2026Q1 $7M
2026Q2 $3M
2026Q3E $3M
2026Q4E $3M
2027Q1E $3M
2027Q2E $4M
2027Q3E $4M
2027Q4E $4M
2028Q1E $4M
2028Q2E $4M
2028Q3E $4M
2028Q4E $4M
2029Q1E $5M
2029Q2E $5M
2029Q3E $5M
2029Q4E $5M
2030Q1E $5M
2030Q2E $5M
2030Q3E $6M
2030Q4E $6M
2031Q1E $6M
2031Q2E $6M

Assumptions & reasoning

  • Deliberately aseasonal. Two post-launch windows give factors of [0.0, 0.0, 1.6, 2.4] and [1.0, 0.0, 1.0, 2.0] - a window-to-window spread as large as the factors themselves, on a base where a $1M rounding step moves a factor by more than 0.10. That is launch noise, not a repeating shape.
  • The EC contract is for 'up to' 24 million doses. Turning it into revenue would require inventing a price per dose and a delivery schedule, neither of which Moderna has published, so the line is held on its disclosed run rate.
  • No RSV-specific cost of sales is disclosed anywhere, so this vertical carries the same blended product gross margin as the COVID line. If RSV economics differ materially, the mix effect is unmodelled.
  • The two derived quarters, 2024 Q4 and 2025 Q4, come from the full-year figure less the filed nine-month figure and are flagged estimated.
MRNA model map

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